Abstract The geotechnical monitoring of tailings dams combined with a suitable application of geophysical electrical methods can improve their structure evaluation, allowing several correlations between direct analyses and the resistivity anomaly pattern. Considering this synergy, twenty-three electrical resistivity sections (ERT) were acquired along the beach, abutments, and central part of a dam, totalizing 10,776 m of dataset. After the interpretation of each ERT section, comparing the anomaly ranges with the water level meters measurements, three resistivity zones were defined: Zones of low resistivity (<64 ohm-m), correlated to regions of high humidity; zones of high resistivity (> 357 ohm-m), interpreted as dry zones, and regions with intermediate resistivity values, located between these limits. The groundwater surface generated from the interpretation of the electrical resistivity dataset and the groundwater surface acquired from the water level gauges were almost coincident. On the right abutment, the conductive anomalies showed remarkable continuity, suggesting a high moisture content in this region with strong gradients (200 mV) directed towards the zone of low resistivity values identified in the sections. The analysis showed a robust correlation of the ERT data with localized physical geotechnical measurements, valuable for monitoring dam integrity, overseeing the structure's response to climate and operational changes, and ultimately mitigating the risks of failure. The results of this study support the adoption of a seasonal 4D electrical resistivity survey as an effective tool to monitor and manage surface and high humidity zones, key indicators of dam integrity throughout the entire structure.

ABSTRACT This paper presents a graphical interface called EPIGUI, which allows the study of the dynamics of an infectious disease spread using compartmental models in combination with complex networks. This interface aims at considering stochastic factors that govern the evolution of an infection in a network. Moreover, it provides simple tools to create networks of agents and to define the epidemiological parameters of outbreaks. There are six common infectious disease models (SI, SIS, SIR, SIRS, SEIR, and SEIRS) or a user can provide another model, combining compartments. Moreover, in the simulations the user can either include a synthetic network generated according to a network model (random, small-world, scalefree, modular, or hierarchical) or a real network. This approach can help understand the paths followed by outbreaks in a given community and design new strategies to prevent and to control them. EPIGUI Moreover SI, SI (SI SIS SIR SIRS SEIR SEIRS compartments random, random (random smallworld, smallworld small world, world small-world scalefree modular hierarchical them

Resumo O presente artigo tem como objetivo analisar as hipóteses em que é possível a substituição de sanção unilateral decorrente de infrações contratuais pelo acordo administrativo, bem como os critérios a serem observados para escolha entre o acordo ou o ato unilateral sancionatório. Para tanto, será feita a análise dos dispositivos normativos que autorizam a adoção da consensualidade na Administração Pública brasileira e os casos em que é possível a substituição do ato administrativo unilateral pela bilateralidade. Após a definição dos referidos pressupostos, será analisada a existência de autorização no Direito brasileiro para a substituição da atividade sancionatória unilateral, no âmbito dos contratos administrativos, por acordos. Em seguida, serão apreciados os critérios balizadores que devem ser utilizados pela Administração para decidir entre celebrar o acordo ou aplicar a sanção administrativa unilateral em caso de ocorrência de infrações administrativas contratuais. Ao final, a conclusão apreciará o processo de tomada de decisão pela Administração com base em tais critérios balizadores. sancionatório tanto bilateralidade pressupostos administrativos acordos seguida final

Abstract This article aims to analyze the hypotheses in which it is possible to replace a unilateral sanction resulting from contractual breaches by an administrative agreement, as well as the criteria to be observed when choosing between an agreement or a unilateral sanctioning act. To this end, an analysis will be made of the normative provisions that authorize the adoption of consensus in the Brazilian Public Administration and the cases in which it is possible to replace the unilateral administrative act with bilaterality. After defining these assumptions, the existence of authorization in Brazilian law for the replacement of unilateral sanctioning activity, within the scope of administrative contracts, by agreements will be analyzed. Then, the guiding criteria that must be used by the Administration to decide between entering into the agreement or applying the unilateral administrative sanction in the event of contractual administrative infractions will be assessed. In the end, the conclusion will assess the decision-making process by the Administration based on such guiding criteria. end bilaterality assumptions activity contracts analyzed Then assessed decisionmaking decision making

ABSTRACT. The objective of this study was to evaluate the transmissibility of F. verticillioides, in corn seeds, when inoculated in different phenological stages. The plants were inoculated with the pathogen at the following stages: V7, V9, R1, R2, R4, and R6. The experiments were conducted in pots, in a completely randomized design, with six replications. The fungus infection rate in the seeds was verified through the health test (Blotter Test). The significance of the contrast between the phenological stages and in the two experiments (rainy season and dry season), and productivity showed plant-seed transmission of F. verticillioides in all phenological stages. The PCR technique was able to reveal up to the lowest level, 1% incidence of F. verticillioides in corn seeds. There was a significant difference between the times of plant inoculation and the incidence of the fungus in the seeds. Plants inoculated in the reproductive phase transmitted F. verticillioides for seeds with the highest rate of infection, in the two experiments, in the rainy season (V7 - 48; V9 - 46; R1 - 77.33; R2 - 84; R4 - 96; R6 - 96.67; and Test - 14.67%), and dry season (V7 - 46.67; V9 - 66; R1 - 75.33; R2 - 95.33; R4 - 98; and R6 - 97.33%). In this way, the present work demonstrated that in the reproductive phenological stages R2, R4, and R6, the corn plant was more susceptible to infection with F. verticillioides, and that it also resulted in a decrease in grain productivity.

Abstract Gaucher disease (GD) is one of the most common lysosomal disorders, occurring in approximately 1 in 40,000 live births worldwide. Since 2014 enzyme replacement therapy (ERT) with taliglucerase alfa has been the treatment of choice for adult patients with GD in Brazil. The aim of this study was to evaluate the long-term efficacy and safety of taliglucerase alfa in a cohort of Brazilian patients treated at a referral center for inborn errors of metabolism. All patients who received at least one infusion of the enzyme at the study center were considered eligible to participate. Patients were followed for adverse reactions and events throughout the study period. Platelets, hemoglobin, chitotriosidase activity, bone marrow burden (BMB) score, bone mineral density, and the severity score index (SSI) were analyzed. For patients who were switched to taliglucerase alfa from imiglucerase, the same variables were compared before and after the switch. At 9-year follow-up, all parameters of interest had remained stable or improved. The overall rate of adverse events was lower than in other studies that evaluated long-term ERT with taliglucerase, and no serious adverse events were considered related to treatment. Based on our findings, ERT with taliglucerase alfa is an effective and safe approach for treatment of patients with GD.

Resumo Objetivo Analisar a concordância, em relação ao percentil 90, das medidas ultrassonográficas da circunferência abdominal (CA) e peso fetal estimado (PFE), entre as tabelas da Organização Mundial de Saúde (OMS) e do International Fetal and Newborn Growth Consortium for the 21st Century integrowth-21st, bem como em relação ao peso ao nascer em fetos/recém-nascidos de mães diabéticas. Métodos Estudo retrospectivo com dados de prontuários de 171 gestantes diabéticas, com gestações únicas, seguidas entre Janeiro de 2017 e Junho de 2018. Foram analisados dados da CA e do PFE na admissão (a partir de 22 semanas) e no pré-parto (até 3 semanas). Essas medidas foram classificadas em relação ao percentil 90. O coeficiente Kappa foi utilizado para analisar a concordância entre as tabelas da OMS e Intergrowth-21st, assim como, por tabela de referência, entre as medidas e o peso ao nascer. Resultados O estudo da OMS relatou 21,6% dos recém nascidos grandes para a idade gestacional (GIG) enquanto que o estudo do intergrowth-21st relatou 32,2%. Ambas as tabelas tiveram fortes concordâncias na avaliação da CA inicial e final e PFE inicial (Kappa= 0,66, 0,72 e 0,63, respectivamente) e concordância quase perfeita em relação ao PFE final (Kappa= 0,91).Emrelação ao peso ao nascer, asmelhores concordâncias foram encontradas para aCAinicial (OMS: Kappa= 0,35; intergrowth-21st: Kappa= 0,42) e como PFE final (OMS: Kappa = 0,33; intergrowth-21st: Kappa= 0,35). Conclusão A CA inicial e o PFE final foram os parâmetros de melhor concordância em relação à classificação do peso ao nascer. As tabelas da OMS e intergrowth-21st mostraram alta concordância na classificação das medidas ultrassonográficas em relação ao percentil 90. Estudos são necessários para confirmar se alguma dessas tabelas é superior na previsão de resultados negativos a curto e longo prazo no grupo GIG.

Abstract Objective To analyze the agreement, in relation to the 90th percentile, of ultrasound measurements of abdominal circumference (AC) and estimated fetal weight (EFW), between the World Health Organization (WHO) and the International Fetal and Newborn Growth Consortium for the 21st Century (intergrowth-21st) tables, as well as regarding birth weight in fetuses/newborns of diabetic mothers. Methods Retrospective study with data from medical records of 171 diabetic pregnant women, single pregnancies, followed between January 2017 and June 2018. Abdominal circumference and EFW data at admission (from 22 weeks) and predelivery (up to 3 weeks) were analyzed. These measures were classified in relation to the 90th percentile. The Kappa coefficient was used to analyze the agreement of these ultrasound variables between the WHO and intergrowth-21st tables, as well as, by reference table, these measurements and birth weight. Results The WHO study reported 21.6% large-for-gestational-age (LGA) newborns while the intergrowth-21st reported 32.2%. Both tables had strong concordances in the assessment of initial AC, final AC, and initial EFW (Kappa = 0.66, 0.72 and 0.63, respectively) and almost perfect concordance in relation to final EFW (Kappa = 0.91). Regarding birth weight, the best concordances were found for initial AC (WHO: Kappa = 0.35; intergrowth-21st: Kappa= 0.42) and with the final EFW (WHO: Kappa = 0.33; intergrowth- 21st: Kappa = 0.35). Conclusion The initial AC and final EFW were the parameters of best agreement regarding birth weight classification. The WHO and intergrowth-21st tables showed high agreement in the classification of ultrasound measurements in relation to the 90th

ABSTRACT Gaucher disease (GD) is an autosomal recessive lysosomal disorder caused by a disturbance in the metabolism of glucocerebroside in the macrophages. Most of its manifestations – hepatosplenomegaly, anemia, thrombocytopenia, and bone pain – are amenable to a macrophage-target therapy such as enzyme replacement. However, there is increasing evidence that abnormalities of the liver persist despite the specific GD treatment. In this work, we adapted histomorphometry techniques to the study of hepatocytes in GD using liver tissue of treated patients, developing the first morphometrical method for canalicular quantification in immunohistochemistry-stained liver biopsies, and exploring histomorphometric characteristics of GD. This is the first histomorphometric technique developed for canalicular analysis on histological liver biopsy samples.

Abstract Objectives: To characterize cases of suspected congenital disorders of glycosylation (CDG) investigated in a laboratory in southern Brazil using the transferrin isoelectric focusing TfIEF test from 2008 to 2017. Method: Observational, cross-sectional, retrospective study. The laboratory records of 1,546 individuals (median age = 36 months, 25–75 IQR = 10–108; males = 810) submitted to the TfIEF test during the period were reviewed. Results: Fifty-one individuals (3%) had an altered TfIEF pattern (5 ± 2.8 cases/year; median age = 24 months, 25–75 IQR = 11–57 months; males = 27, 53%). For 14 of them, data on diagnosis conclusion were available (classic galactosemia = 4; hereditary fructose intolerance = 4; peroxisomal diseases = 2; PMM2-CDG = 2; MPDU1-CDG = 1; SLC35A2-CDG = 1).Comparing the cases with the normal and altered TfIEF patterns, there was a higher prevalence of altered cases in the age group from 11 months to 3 years. There was an increase in the likelihood of change in TfIEF, especially in the presence of inverted nipples or liver disease. Conclusions: The data suggest that the investigation of a case with suspected CDG is a complex problem, being aggravated by the existence of other IEMs (inborn errors of metabolism) associated with altered TfIEF pattern and lack of access to confirmatory tests. The presence of inverted nipples and liver disease, especially in individuals aged 11 months to 3 years, should suggest the need for TfIEF investigation.

Resumo Objetivos: Caracterizar os casos com suspeita de CDG investigados em laboratório do sul do Brasil pelo exame de IEFTF de 2008 a 2017. Metodologia: Estudo observacional, transversal, retrospectivo. Foram revisadas as fichas laboratoriais de 1.546 indivíduos (mediana de idade = 36 meses, IQ 25-75 = 10-108; sexo masculino = 810) que fizeram o exame de IEFTF no período. Resultados: Cinquenta e um indivíduos (3%) apresentaram padrão alterado na IEFTF (5 ± 2,8 casos/ano; mediana de idade = 24 meses, IQ 25-75 = 11-57 meses; sexo masculino = 27, 53%). Para 14 deles, estavam disponíveis dados sobre a conclusão do diagnóstico (galactosemia clássica = 4; intolerância hereditária à frutose = 4; doenças peroxissomais = 2; PMM2-CDG = 2; MPDU1-CDG = 1; SLC35A2-CDG = 1). Comparando os casos com padrão normal e alterado na IEFTF, houve maior prevalência de casos alterados na faixa etária de 11 meses a 3 anos. Verificou-se um aumento na probabilidade de alteração na IEFTF principalmente na presença de mamilos invertidos ou de hepatopatia. Conclusões: Os nossos dados sugerem que a investigação de um caso com suspeita de CDG é complexa, é agravada pela existência de outros EIM associados a padrão alterado na IEFTF e pela falta de acesso a exames confirmatórios. A presença principalmente de mamilos invertidos e de hepatopatia em indivíduos na faixa etária de 11 meses a 3 anos deve sugerir a necessidade de investigação por IEFTF.

RESUMO O objetivo deste trabalho foi comparar a eficácia dos modelos de Programação por Metas como ferramenta de regressão não linear, com os métodos de ajustes não lineares clássicos. Aplicou-se os modelos a dados experimentais de inativação de Salmonella spp. em carne móıda suína. A investigação da eficiência dos métodos foi realizada pelo cálculo do erro absoluto.

ABSTRACT The aim of this work was to compare the effectiveness of Goal Programming models, as a nonlinear regression tool, with the classical nonlinear fitting methods. The models were applied to experimental data of inactivation Salmonella spp. in ground pork. The investigation of the methods’ efficiency was made by calculation of the maximum and absolute errors.

Abstract Chronic non-communicable diseases (NCDs) prevalence has been growing, hence the importance of studying food alternatives with reduced sodium content sensory well accepted. Develop culinary preparations reduced in sodium, with addition of glutamic acid-rich ingredients, and evaluate their sensory acceptance. Research about use of glutamic acid-rich ingredients in recipes was done. Recipes were developed, aiming good sensory acceptance; their salt content was estimated by using TACO and USDA’s food composition table. They were later submitted to sensory analysis, in which was applied 9-point hedonic scale (global acceptance and flavor), and linear scale of 10 cm (salt intensity). Data was analyzed by ANOVA and Tukey Test (p < 0.05) with software FIZZ Biosystemes. Herbs pie samples with parmesan cheese had better acceptance and salt intensity was perceived as moderate. Bruschetta samples, with tomatoes, were well accepted regardless the presence of refined salt or herbs; and had a harmonious salt intensity perception. Salt intensity was considered adequate on chicken stroganoff samples while champignon mushrooms provided better global acceptance. All samples had 50-60% less salt than traditional recipes. Ingredients naturally rich in glutamic acid (parmesan cheese, tomatoes and mushrooms) are good for strategies of sodium content reduction in culinary preparations, without reduce sensorial acceptance.

RESUMO A teoria de redes complexas constitui um suporte natural para o estudo da propagação de uma doença infecciosa. Neste trabalho, apresentamos um estudo da propagação de uma doença infecciosa com o uso de tal teoria em conjunto com o Modelo Baseado em Indivíduos. Mais especificamente, utilizamos diversos modelos de redes complexas amplamente conhecidos na literatura para verificar seus efeitos topológicos na propagação de uma doença. De modo geral, observamos que redes complexas com propriedades distintas resultam em curvas de indivíduos infectados com comportamentos também distintos, e desta forma, que a proliferação de uma dada doença é altamente sensível ao modelo de rede utilizado. Observamos a erradicação da doença quando adotada a estratégia de vacinação de 10% da população em combinação com os modelos de redes aleatória, mundo pequeno ou modular. Desta forma, estratégias de controle com enfoque na topologia da rede em estudo podem ser utilizadas com êxito como forma de redução ou até mesmo de erradicação de uma doença infecciosa.

ABSTRACT The complex network theory constitutes a natural support for the study of a disease propagation. In this work, we present a study of an infectious disease spread with the use of this theory in combination with the Individual Based Model. More specifically, we use several complex network models widely known in the literature to verify their topological effects in the propagation of the disease. In general, complex networks with different properties result in curves of infected individuals with different behaviors, and thus, the growth of a given disease is highly sensitive to the network model used. The disease eradication is observed when the vaccination strategy of 10% of the population is used in combination with the random, small world or modular network models, which opens an important space for control actions that focus on changing the topology of a complex network as a form of reduction or even elimination of an infectious disease.

Abstract Background: Psoriatic Arthritis is the spondyloarthritis associated with psoriasis, which is often related to high mortality due to cardiovascular causes. Objectives: To quantify cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity and smoking) and to measure risk by the Global Cardiovascular Risk Score in patients with psoriatic arthritis. Methods: Patients with psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis, aged between 30 and 74 years and without any other clinically manifest chronic inflammatory disease, atherosclerotic disease or heart failure were included. After an interview, clinical examination and data extraction from medical records, risk stratification was performed using a calculator available on the online platform of the Framingham Heart Study. We considered p < 0.05 as significant. Chi-square test and Fisher’s exact test were used to compare frequencies, as well as correlation measurements. Results: 45 patients were included, 68,9% of which were women and the mean age was 53,94 years. Dyslipidemia was confirmed in approximately 93%, hypertension in 46%, obesity in 40%, 33.3% were diabetics and, 13.3%, smokers; 95% had increased abdominal circumference. It was observed that 53% had high cardiovascular risk, 29% had intermediate risk and 18% had low risk. Individuals with altered C-reactive protein and erythrocyte sedimentation rate presented, respectively, higher levels of LDL-C and total cholesterol. Conclusions: There was a high occurrence of risk factors and the majority of the sample was stratified into high or intermediate cardiovascular risk.

Bioactive glasses (BG) are versatile materials for various biomedical applications due to their capacity to bond to hard and soft tissues. These materials can be produced with different nominal compositions, such that include fluoride ions. Fluorine-containing-BG (BGF) can be produced by the sol-gel method, and its properties can be changed by altering the synthesis parameters. Here, BGF particle size between 235 nm-390 nm were obtained through sol-gel method assisted by ultrasound energy (BGU) or through mechanical stirring (BGM). The BGM and BGU particles showed highly dispersed spherical shape, moreover BGM are mesoporous and BGU are dense structures, indicating mixing mode can alter mainly the material textural characteristics. All compositions have apatite forming ability, verified by DRX from 14 days in SBF. The results showed CaF2 on the surface of BGF particles, indicating that part of F ions was not incorporated in the material network. The samples did not show any cytotoxicity towards human cells in Cellular Metabolic Activity and Calcein assays. This study showed that mechanical agitation was more efficient to produce mesoporous particles to be applied as carrier of drugs and molecules to the biological environment, so BGM can be used as a more efficient biomaterial for such applications.

Resumo Objetivo Determinar o efeito da caminhada em esteira sobre a frequência cardíaca materna (FCM) e parâmetros cardiotocográficos (batimentos cardiofetais basais [BCFs], movimentos ativos fetais [MAFs], número de acelerações e desacelerações e variabilidade de curta [STV] e longa [LTV] duração da frequência cardíaca fetal) em gestantes na 36a semana. Métodos Foi realizado umensaio clínico não randomizado e aberto com 88 gestantes saudáveis submetidas a caminhada de moderada intensidade na esteira e a cardiotocografia computadoriza em 3 momentos de 20 minutos (antes, durante e após a caminhada). Resultados A média dos BCFs diminuiu durante a caminhada, retornando a níveis prévios (antes: 137 bpm; durante: 98 bpm; após: 140 bpm; p<0,001), com bradicardia ocorrendo em 56% dos fetos nos primeiros 10 minutos do exercício, e em 47% após 20 minutos. A bradicardia fetal não foi observada em outrosmomentos (antes ou depois). As médias da STV e da LTV foram 7,9, 17,0 e 8,0milissegundos (p<0,001) e 7,6, 10,7 e 7,6 bpm (p=0,002) antes, durante e após a caminhada, respectivamente. Amédia dos números dos MAFs em 1 hora foi 29,9, 22,2 e 45,5, respectivamente, nos três momentos (p<0,001). Nas mulheres com sobrepeso/obesidade, a média da FCM foi menor (p=0,02). Após a análise de regressão logística, duas variáveis permaneceram significativamente associadas a bradicardia: aptidão maternal na 28a semana de gravidez (efeito protetor) e peso materno (aumento do risco). Conclusão Em fetos saudáveis, o exercício físico mostrou-se seguro, uma vez que, embora os BCFs e osMAFs diminuam durante a caminhada na esteira, foi observado um aumento da SVT e da LTV.

Abstract Objective To determine the effect of treadmill walking on maternal heart rate (MHR) and cardiotocographic parameters (basal fetal heart rate [FHR], active fetal movements [AFM], number of accelerations and decelerations, and short-term variation [STV] and long-term variation [LTV] of fetal heart rate) in pregnant women at 36 weeks. Methods A nonrandomized, open clinical trial involving 88 healthy pregnant women submitted to moderate intensity walking and computed cardiotocography in 3 20- minute periods (resting, treadmill walking, and postexercise recovery). Results The mean FHR decreased during walking (resting: 137 bpm; treadmill: 98 bpm; recovery: 140 bpm; p<0.001), with bradycardia occurring in 56% of the fetuses in the first 10minutes of exercise, and in 47% after 20minutes. Bradycardia was not detected in the other phases. The mean STV and HV were 7.9, 17.0, and 8.0 milliseconds (p<0.001) and 7.6, 10.8 and 7.6 bpm (p=0.002) in the resting, walking and recovery phases, respectively. Themean number of fetalmovements in 1 hour was 29.9, 22.2 and 45.5, respectively, in the 3 periods (p<0.001). In overweight/obese women, the mean FHR was lower (p=0.02). Following the logistic regression analysis, two variables remained significantly associated with bradycardia: maternal fitness in the 28th week of pregnancy (protective effect) and maternal weight (increased risk). Conclusion In healthy fetuses, physical exercise proved to be safe, since, although FHR and AFM decreased during treadmill walking, an increase in SVT and LTV was observed.

Resumo Este estudo objetivou analisar as vivências de prazer-sofrimento de oito assistentes em administração de uma universidade que solicitaram remoção motivada por alguma insatisfação. O estudo, realizado entre setembro de 2013 e agosto de 2015, referenciou-se na psicodinâmica do trabalho. Optou-se por entrevistas semiestruturadas e pela análise de conteúdo. Diferentes aspectos relacionados ao trabalho emergiram de três categorias centrais: prazer; sofrimento; estratégias defensivas e luta por reconhecimento. Em relação ao sofrimento, os entrevistados apontaram o estigma e a invisibilidade das atividades-meio, preocupação constante com aspectos conflituosos do trabalho, somatização e intensificação do trabalho. Já as vivências de prazer foram relacionadas às condições salariais, qualificação no trabalho, retribuição simbólica e possibilidades de reconhecimento. Em face do sofrimento, destacaram-se estratégias defensivas na luta pelo reconhecimento: priorização da qualificação; verbalização dos problemas; e busca de instrumentos de proteção de conflitos, entre outras. Na expectativa de minimizar insatisfações, os entrevistados utilizaram a remoção, que se revelou exitosa em parte dos casos, auxiliando-os na ressignificação do trabalho e preservação da saúde. Esse instrumento, porém, não atua na origem das vivências de prazer-sofrimento. O sofrimento, além de intrínseco ao trabalho, situa-se em um contexto organizacional que cria entraves à possibilidade individual de ressignificá-lo por meio da remoção.

Abstract TThis study aimed to analyze the experiences of pleasure-suffering of eight assistants in administration of a university that requested removal motivated by some dissatisfaction. The study, carried out between September of 2013 and August of 2015, was referenced in the Psychodynamics of Work. We chose semi-structured interviews and content analysis. Different aspects related to work emerged from three central categories: pleasure; suffering; defensive strategies and fight for recognition. Concerning suffering, the interviewees pointed out the stigma and invisibility of the middle activities, constant concern with conflicting aspects of work, somatization and work intensification. The experiences of pleasure were related to salary conditions, work qualification, symbolic retribution and possibilities of recognition. Faced with suffering, defensive strategies were highlighted in the fight for recognition: prioritizing qualification; verbalization of problems; and search for instruments of conflict protection, among others. In the expectation of minimizing dissatisfaction the interviewees used the removal that proved to be successful in part of the cases, helping them in the re-signification of work and preservation of health. This instrument, however, does not act in the origin of the experiences of pleasure-suffering. Suffering, besides being intrinsic to work, is situated in an organizational context that creates obstacles to the individual possibility of re-signifying it through removal.

Resumen Este estúdio objetivó analizar las expêriencias de placer-sufrimiento de ocho auxiliares administrativos em una universidad que solicitaron la remoción motivada por cierta insatisfacción. El estúdio, realizado entre septiembre de 2013 y agosto de 2015, se referenció en la Psicodinámica del Trabajo. Se optó por entrevistas semiestructuradas y por el análisis de contenido. Los diferentes aspectos relacionados con el trabajo surgieron de tres categorías centrales: el placer; sufrimiento; estrategias de defensa y lucha por el reconocimiento. Em relación com el sufrimiento, los entrevistados señalaron estigma y la invisibilidad de las actividades intermedias, preocupación constante de los aspectos conflictivos de trabajo, la somatización y la intensificación del trabajo. Ya las experiencias de placer estaban relacionados con las condiciones salariales de trabajo, cualificación, recompensa simbólica y posibilidades de reconocimiento. Ante el sufrimiento se destacó estrategias de defensa en la lucha por el reconocimiento: priorizar la cualificación; verbalización de los problemas; y la búsqueda de instrumentos de protección de conflictos, entre otros. En previsión de minimizar insatisfacciones lós entrevistados utilizan la remoción que ha demostrado tener éxito en parte, ayudándoles en la resignificación del trabajo y la preservación de la salud. Este instrumento, sin embargo, no actúa sobre la fuente de experiencias de placer-sufrimiento. El sufrimiento, además de ser intrínseco a ló trabajo, se encuentra en un contexto organizacional que dificulta la posibilidad individual de ressignificár-lo mediante la remoción.